Pharmacokinetic and pharmacodynamic herb–drug interactions of common over-the-counter pain medications

Chung Kai Sun, Tung Hu Tsai*

*此作品的通信作者

研究成果: Review article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Pain is one of the most common reasons for seeking medical intervention, and self-medication with over-the-counter medications and/or traditional herbal remedies has become increasingly popular. In this review, original articles on understanding possible herb–drug interactions between traditional herbs and four major pain medications—acetaminophen, aspirin, ibuprofen and naproxen—are compiled and analyzed. In terms of analytical methods, high-performance liquid chromatography using an isocratic eluent system coupled to biological sample clean-up is the most common, while a wide variety of detectors have been observed, including a photodiode array, variable wavelength detector, electrochemical detector and tandem mass spectrometer. Both synergistic and anti-synergistic effects were observed for acetaminophen and aspirin, while only synergistic effects have been found for naproxen. Currently, no interactions have been reported for ibuprofen.

原文English
文章編號e5591
期刊Biomedical Chromatography
37
發行號7
DOIs
出版狀態Published - 7月 2023

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