Pharmacogenomics for personalized pain medicine

Tai-Ming Ko, Chih Shung Wong, Jer Yuarn Wu, Yuan Tsong Chen*

*此作品的通信作者

研究成果: Review article同行評審

21 引文 斯高帕斯(Scopus)

摘要

Pharmacogenomics aims to unravel the way that human genetic variation affects drug efficacy and toxicity. Genome-wide association studies and candidate gene findings suggest that genetic approaches may help choose the most appropriate drug and dosage while preventing adverse drug reactions (ADRs). Pain is an unpleasant feeling that usually results from tissue damage. The management of different types of pain (acute, chronic, inflammatory, neuropathic, or cancer) is challenging. Currently, drug intervention is the first-line therapy for resolving pain. However, differences in drug efficacy between individuals are common with pain medications. Moreover, some patients experience ADRs after being treated with specific pain drugs. This review discusses the use of drugs for pain management in the context of the recent pharmacogenomic studies on ADRs and drug efficacy.

原文English
頁(從 - 到)24-30
頁數7
期刊Acta Anaesthesiologica Taiwanica
54
發行號1
DOIs
出版狀態Published - 1 3月 2016

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