TY - JOUR
T1 - Parasympathetic activity correlates with early outcome in patients with large artery atherosclerotic stroke
AU - Chen, Po Lin
AU - Kuo, Terry B.J.
AU - Yang, Cheryl C.H.
N1 - Funding Information:
This study was supported by a grant (NSC 100-2627-B-010-002 ) from the National Science Council (Taiwan) and by a grant ( 100AC-B3 ) from the Ministry of Education, Aim for the Top University Plan .
PY - 2012/3/15
Y1 - 2012/3/15
N2 - To evaluate the associations between autonomic function and early stroke outcome in different subtypes of cerebral infarct, 24 patients with acute large artery atherosclerotic infarction (LAA), 26 patients with acute lacunar infarction (LAC), and 19 control subjects were prospectively recruited. Stroke outcome by the National Institute of Health Stroke Score (NIHSS) and heart rate variability (HRV) by power spectral analysis were recorded. The LAA group had lower high-frequency power (HF, P = 0.017), lower normalized HF (P = 0.002), higher normalized low-frequency power (LF%, P = 0.016), and higher ratio of LF to HF (P = 0.003) than both the LAC and control groups. Multivariate regression analysis in the LAA group showed that HF significantly correlated with early outcome (standardized coefficient = - 0.486, P = 0.016), and HF less than 3.9 [ln(ms 2)] was an independent risk factor for NIHSS ≥ 4 at seventh day after admission (odd ratio = 6.00, 95% confidence interval 1.02-35.37, P = 0.048). There was no significant correlation between any HRV parameter and early stroke outcome in the LAC group. There were different autonomic function properties between LAA and LAC groups, and depressed parasympathetic modulation was associated with worse early outcome in patients with LAA.
AB - To evaluate the associations between autonomic function and early stroke outcome in different subtypes of cerebral infarct, 24 patients with acute large artery atherosclerotic infarction (LAA), 26 patients with acute lacunar infarction (LAC), and 19 control subjects were prospectively recruited. Stroke outcome by the National Institute of Health Stroke Score (NIHSS) and heart rate variability (HRV) by power spectral analysis were recorded. The LAA group had lower high-frequency power (HF, P = 0.017), lower normalized HF (P = 0.002), higher normalized low-frequency power (LF%, P = 0.016), and higher ratio of LF to HF (P = 0.003) than both the LAC and control groups. Multivariate regression analysis in the LAA group showed that HF significantly correlated with early outcome (standardized coefficient = - 0.486, P = 0.016), and HF less than 3.9 [ln(ms 2)] was an independent risk factor for NIHSS ≥ 4 at seventh day after admission (odd ratio = 6.00, 95% confidence interval 1.02-35.37, P = 0.048). There was no significant correlation between any HRV parameter and early stroke outcome in the LAC group. There were different autonomic function properties between LAA and LAC groups, and depressed parasympathetic modulation was associated with worse early outcome in patients with LAA.
KW - Acute ischemic stroke
KW - Autonomic function
KW - Early outcome
KW - Lacunar infarction
KW - Large artery atherosclerotic infarction
KW - Parasympathetic function
UR - http://www.scopus.com/inward/record.url?scp=84857192135&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2011.10.034
DO - 10.1016/j.jns.2011.10.034
M3 - Article
C2 - 22118864
AN - SCOPUS:84857192135
SN - 0022-510X
VL - 314
SP - 57
EP - 61
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -