Palladium-catalyzed alpha-arylation of indolin-3-ones

Yu-Hsuan Chang; Wan-Ling Peng; I. Chia Chen; Hsin-Yun Hsu; Yen-Ku Wu

doi:10.1039/d0cc00435a

Palladium-catalyzed alpha-arylation of indolin-3-ones

Yu-Hsuan Chang, Wan-Ling Peng, I. Chia Chen, Hsin-Yun Hsu, Yen-Ku Wu^*

^*此作品的通信作者

研究成果: Article › 同行評審

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摘要

A method for the catalytic alpha-arylation of indolin-3-ones was developed. The catalytic system comprising Pd(dba)(2) and PAd(3) was found to be optimal for the transformation. The protocol features broad functional group compatibility in that a range of arylated indoxyl derivatives bearing a fully substituted carbon center was synthesized with high efficiency. A preliminary bioassay study revealed that the selected indole-substituted indolin-3-ones exhibit favorable cytotoxic activities against HCT-116 cancer cell line.

原文	English
頁（從 - 到）	4660-4663
頁數	4
期刊	Chemical Communications
卷	56
發行號	34
DOIs	https://doi.org/10.1039/d0cc00435a
出版狀態	Published - 30 4月 2020

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10.1039/d0cc00435a

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AU - Wu, Yen-Ku

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AB - A method for the catalytic alpha-arylation of indolin-3-ones was developed. The catalytic system comprising Pd(dba)(2) and PAd(3) was found to be optimal for the transformation. The protocol features broad functional group compatibility in that a range of arylated indoxyl derivatives bearing a fully substituted carbon center was synthesized with high efficiency. A preliminary bioassay study revealed that the selected indole-substituted indolin-3-ones exhibit favorable cytotoxic activities against HCT-116 cancer cell line.

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Palladium-catalyzed alpha-arylation of indolin-3-ones

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