摘要
Described is a deprotonative ?-arylation reaction of Meyers s chiral bicyclic lactams (MCBLs) under palladium catalysis, and a substrate-dependent post-transformation. When the bridgehead carbon of the MCBLs is substituted with a methyl or an ethyl group, the initial arylation product undergoes a further rearrangement reaction to give a conjugated framework. On the other hand, substrates bearing a bridgehead isopropyl or aryl group are converted into the corresponding exo-arylation products. Preliminary studies indicated that the rearrangement pathway was promoted by deprotonation and was independent of palladium catalysis. In addition to mechanistic interests, this study demonstrates a modular and divergent synthesis of functionalized lactams.
原文 | English |
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頁(從 - 到) | 1145-1148 |
頁數 | 4 |
期刊 | Synlett |
卷 | 35 |
發行號 | 10 |
DOIs | |
出版狀態 | Published - 28 5月 2024 |