Pain

Jun Chen*, Ji Sheng Han, Zhi Qi Zhao, Feng Wei, Jen Chuen Hsieh, Lan Bao, Andrew C.N. Chen, Yi Dai, Bi Fa Fan, Jian Guo Gu, Shuang Lin Hao, San Jue Hu, Yong Hua Ji, Yong Jie Li, Yun Qing Li, Qing Lin, Xian Guo Liu, Yan Qing Liu, Yan Lu, Fei LuoChao Ma, Yun Hai Qiu, Zhi Ren Rao, Lin Shi, Bai Chuang Shyu, Xue Jun Song, Jing Shi Tang, Yuan Xiang Tao, You Wan, Jia Shuang Wang, Ke Wei Wang, Yun Wang, Guang Yin Xu, Tian Le Xu, Hao Jun You, Long Chuan Yu, Sheng Yuan Yu, Da Ying Zhang, De Ren Zhang, Jun Ming Zhang, Xu Zhang, Yu Qiu Zhang, Min Zhuo

*此作品的通信作者

研究成果: Chapter同行評審

摘要

Pain is one of the most common causes of suffering. The physiological function of pain is to alert the body of potentially noxious conditions encountered from the external or internal environment. Pain can be differentiated into acute pain and chronic pain according to its duration, with 3 months as a tentative defining point in humans. Acute pain is good for protection from dangerous health issues and relatively easy to control. Chronic pain, on the other hand, is absolutely annoying and notoriously difficult to manage. Chronic pain can be induced by various causes, such as inflammatory or metabolic disorders of the peripheral tissue, musculoskeletal strain, peripheral or central nervous lesion and diseases, etc., yet their common mechanism is hypersensitivity of the pain transmission and perception systems, which may result in a structural disorganization. The suffering from chronic pain has been a powerful driving force for pain research both in academic institutions and in the industry. This chapter focuses on the system of noxious signal transmission, from the ion channel and nociceptor to the psychological reaction, from the ascending pain perception pathways to the descending pain modulatory pathways, being facilitatory or inhibitory. Principles of biomedical interventions on acute and chronic pain are also outlined.

原文English
主出版物標題Neuroscience in the 21st Century
主出版物子標題From Basic to Clinical, Second Edition
發行者Springer New York
頁面1091-1149
頁數59
ISBN(電子)9781493934744
ISBN(列印)9781493934737
DOIs
出版狀態Published - 1 1月 2016

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