P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide

Lei Zhang*, Tung Ping Su, Kwang Choi, Webster Maree, Cheng Ta Li, Ming Yi Chung, Ying Sheue Chen, Ya Mei Bai, Yuan Hwa Chou, Jeffery L. Barker, James E. Barrett, Xiao Xia Li, He Li, David M. Benedek, Robert Ursano

*此作品的通信作者

研究成果: Article同行評審

43 引文 斯高帕斯(Scopus)

摘要

Although suicide represents 1.8% of the global burden of disease, there are few objective assays for suicide risk. Being associated with depressive disorders, which have a high risk of suicide, the proteins P11, P2RX7, and S100β may be biomarkers for a suicidal disposition. We measured levels of p11 and P2RX7 mRNA in peripheral blood mononuclear cells (PBMCs) of 26 psychiatric patients (11 suicide attempters, 15 suicide non-attempters) with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), and 14 normal controls, using quantitative real-time PCR. We also conducted a meta-analysis of microarray data of p11, P2RX7 and S100β from post-mortem prefrontal cortex (PFC) of patients who committed suicide (n = 56) and non-suicide controls (n = 61). We found that PBMC p11 mRNA levels were significantly lower in suicide attempters and higher in suicide non-attempters, when compared to normal controls. The PFC p11 mRNA levels in suicide completers were also lower than non-suicide controls (adjusted p = 0.007). Unlike p11, PBMC P2RX7 mRNA levels were significantly lower than normal controls in all patients including suicide attempters, suicide non-attempters, and suicide completers. In addition, levels of S100β in PFC did not differ between suicide completers and non-suicide controls. These results suggest that PBMC p11 mRNA levels may be a potential adjunctive biomarker for the assessment of suicide risk in mental disorders and warrants a larger translational study to determine its clinical utility.

原文English
頁(從 - 到)435-441
頁數7
期刊Journal of Psychiatric Research
45
發行號4
DOIs
出版狀態Published - 4月 2011

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