Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM

I. Weng Yen, Chien Nan Lee, Ming Wei Lin, Kang Chih Fan, Jung Nan Wei, Kuan Yu Chen, Szu Chi Chen, Yi Yun Tai, Chun Heng Kuo, Chia Hung Lin, Chih Yao Hsu, Lee Ming Chuang, Shin Yu Lin, Hung Yuan Li*

*此作品的通信作者

研究成果: Article同行評審

40 引文 斯高帕斯(Scopus)

摘要

Aim Overweight and obesity are important risk factors of gestational diabetes mellitus (GDM). Clustering of metabolic risk factors in early pregnancy may be a potential pathogenesis between the link of overweight/obesity and GDM. Since it remains unexplored, we investigated if overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM in this cohort study. Methods Total 527 women who visited National Taiwan University Hospital for prenatal care in between November 2013 to April 2018 were enrolled. Risk factors of GDM in the first prenatal visit (FPV) were recorded. Overweight/obesity was defined if body mass index ≥24 kg/ m2. GDM was diagnosed from the result of a 75g oral glucose tolerance test in 24–28 gestational weeks. Results Overweight/obesity was associated with clustering of metabolic risk factors of GDM, including high fasting plasma glucose, high HbA1c, insulin resistance, high plasma triglyceride and elevated blood pressure in FPV (p<0.05). There was a positive relationship between the number of metabolic risk factors and the incidence of GDM (p <0.05). The odds ratios of HbA1c and diastolic blood pressure were higher in overweight/obese women, compared with those in normal-weight women.

原文English
文章編號e0225978
期刊PLoS ONE
14
發行號12
DOIs
出版狀態Published - 1 12月 2019

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