The purpose of this study is to survey nurses' use of the new information system (IS) and to compare the outcomes of the medication errors (MEs) due to the use of this technology. A questionnaire with the system successful model was distributed from October to November 2014(n=210). Additionally, medication errors due to workflow design in patient assessment, MA regulations, MA standard of operation procedure (SOP), double checks, and others were collected before and after the MAIS implementation. The highest scored category is the charting time and the lowest is the screen speed. Nurses are unsatisfied on downtime and intranet speed. Three main MEs factors are: not following MA SOP, no MA regulations, and others based on 275 (before) and 124 (after) incident reports. While nurses valued the MAIS use, network speed has been raised. ME incidents are decreased but the workflow factors are different for both before-after implementation stages.