TY - JOUR
T1 - Optical Trapping Controlled Cocrystallization Dynamics of Acetaminophen and l-Phenylalanine
AU - Wang, Wen Chi
AU - Okano, Kazuki
AU - Yoshikawa, Hiroshi Y.
AU - Sugiyama, Teruki
N1 - Publisher Copyright:
© 2024 The Authors. Published by American Chemical Society.
PY - 2024/7/17
Y1 - 2024/7/17
N2 - Cocrystallization is widely recognized as a crucial process in pharmaceutical manufacturing, allowing for the enhancement of drug properties without compromising the efficacy. In this study, we demonstrate cocrystallization via optical trapping using a focused laser beam. Specifically, we present experimental results focusing on cocrystallization in a binary-solute solution of acetaminophen (Ace) and l-phenylalanine (l-Phe) with a 1:1 molar ratio, utilizing the optical trapping method. While spontaneous nucleation from the binary-solute solution via slow evaporation at room temperature only yields 1:1 hemihydrate cocrystals of Ace and l-Phe, optical trapping also produces l-Phe anhydrous crystals in addition to the cocrystals. Furthermore, we investigate the influence of laser power on the generation probability of these two crystals and on crystallization time, revealing a strong dependency of l-Phe crystal generation on laser power. Additionally, through in situ Raman spectroscopy, we examine temporal changes in local concentration at the laser focus and discuss the underlying mechanisms of the unique crystallization. We believe our findings in this study contribute to advancing understanding of laser-induced crystallization mechanisms and the potential of pharmaceutical cocrystallization, offering novel methodologies for drug development.
AB - Cocrystallization is widely recognized as a crucial process in pharmaceutical manufacturing, allowing for the enhancement of drug properties without compromising the efficacy. In this study, we demonstrate cocrystallization via optical trapping using a focused laser beam. Specifically, we present experimental results focusing on cocrystallization in a binary-solute solution of acetaminophen (Ace) and l-phenylalanine (l-Phe) with a 1:1 molar ratio, utilizing the optical trapping method. While spontaneous nucleation from the binary-solute solution via slow evaporation at room temperature only yields 1:1 hemihydrate cocrystals of Ace and l-Phe, optical trapping also produces l-Phe anhydrous crystals in addition to the cocrystals. Furthermore, we investigate the influence of laser power on the generation probability of these two crystals and on crystallization time, revealing a strong dependency of l-Phe crystal generation on laser power. Additionally, through in situ Raman spectroscopy, we examine temporal changes in local concentration at the laser focus and discuss the underlying mechanisms of the unique crystallization. We believe our findings in this study contribute to advancing understanding of laser-induced crystallization mechanisms and the potential of pharmaceutical cocrystallization, offering novel methodologies for drug development.
UR - http://www.scopus.com/inward/record.url?scp=85197086867&partnerID=8YFLogxK
U2 - 10.1021/acs.cgd.4c00599
DO - 10.1021/acs.cgd.4c00599
M3 - Article
AN - SCOPUS:85197086867
SN - 1528-7483
VL - 24
SP - 6028
EP - 6035
JO - Crystal Growth and Design
JF - Crystal Growth and Design
IS - 14
ER -