Opioid peptides alleviated while naloxone potentiated methamphetamine-induced striatal dopamine depletion in mice

L. Yu*, Y. M. Kuo, C. F.G. Cherng

*此作品的通信作者

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    5 引文 斯高帕斯(Scopus)

    摘要

    Delta opioid peptide [D-Ala2,D-Leu5] enkephalin (DADLE) can partially reverse long-term loss of striatal dopamine transporters induced by multiple doses of methamphetamine via an unknown mechanism. This study was designed to examine the modulating effects of three opioid ligands, DADLE, Leucine enkephalin (L-enk), and naloxone, on the long-lasting dopamine depletion produced by 4 cumulative doses of methamphetamine. Both DADLE (at a dose of 18mg/kg) and L-enk (100μg/kg × 2) effectively attenuated methamphetamine-induced dopamine depletion in the striatum while their protective effects were not blocked by coadministration of naloxone. In contrast, naloxone (10mg/kg × 2) alone potentiated the long-lasting dopamine depletion produced by methamphetamine. Moreover, none of the treatments with DADLE (18mg/kg), L-enk (100μg/kg), or naloxone (10mg/kg) alone affected body temperature. These results suggest that the opioid ligands may, directly or indirectly, modulate this methamphetamine-induced dopamine neurotoxicity in the nigrostriatal system via a temperature-independent mechanism.

    原文English
    頁(從 - 到)1231-1237
    頁數7
    期刊Journal of Neural Transmission
    108
    發行號11
    DOIs
    出版狀態Published - 2001

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