One-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles via A multicomponent [4 + 1] cycloaddition reaction

Ya Shan Hsiao; Bharat D. Narhe; Ying Sheng Chang; Chung-Ming Sun

doi:10.1021/co400075z

One-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles via A multicomponent [4 + 1] cycloaddition reaction

Ya Shan Hsiao, Bharat D. Narhe, Ying Sheng Chang, Chung-Ming Sun^*

^*此作品的通信作者

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摘要

A one-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles has been achieved by a three-component reaction of 2-aminobenzimidazoles with an aromatic aldehyde and an isocyanide. The reaction involving condensation of 2-aminobenzimidazole with an aldehyde is run under microwave activation to generate an imine intermediate under basic conditions which then undergoes [4 + 1] cycloaddition with an isocyanide.

原文	English
頁（從 - 到）	551-555
頁數	5
期刊	ACS Combinatorial Science
卷	15
發行號	10
DOIs	https://doi.org/10.1021/co400075z
出版狀態	Published - 14 10月 2013

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10.1021/co400075z

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title = "One-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles via A multicomponent [4 + 1] cycloaddition reaction",

abstract = "A one-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles has been achieved by a three-component reaction of 2-aminobenzimidazoles with an aromatic aldehyde and an isocyanide. The reaction involving condensation of 2-aminobenzimidazole with an aldehyde is run under microwave activation to generate an imine intermediate under basic conditions which then undergoes [4 + 1] cycloaddition with an isocyanide.",

keywords = "[4 + 1] cycloaddition, imidazo[1,2-a ]benzimidazoles, microwave irradiation, three-component reaction",

author = "Hsiao, {Ya Shan} and Narhe, {Bharat D.} and Chang, {Ying Sheng} and Chung-Ming Sun",

year = "2013",

month = oct,

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doi = "10.1021/co400075z",

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T1 - One-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles via A multicomponent [4 + 1] cycloaddition reaction

AU - Hsiao, Ya Shan

AU - Narhe, Bharat D.

AU - Chang, Ying Sheng

AU - Sun, Chung-Ming

PY - 2013/10/14

Y1 - 2013/10/14

N2 - A one-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles has been achieved by a three-component reaction of 2-aminobenzimidazoles with an aromatic aldehyde and an isocyanide. The reaction involving condensation of 2-aminobenzimidazole with an aldehyde is run under microwave activation to generate an imine intermediate under basic conditions which then undergoes [4 + 1] cycloaddition with an isocyanide.

AB - A one-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles has been achieved by a three-component reaction of 2-aminobenzimidazoles with an aromatic aldehyde and an isocyanide. The reaction involving condensation of 2-aminobenzimidazole with an aldehyde is run under microwave activation to generate an imine intermediate under basic conditions which then undergoes [4 + 1] cycloaddition with an isocyanide.

KW - [4 + 1] cycloaddition

KW - imidazo[1,2-a ]benzimidazoles

KW - microwave irradiation

KW - three-component reaction

UR - http://www.scopus.com/inward/record.url?scp=84885578571&partnerID=8YFLogxK

U2 - 10.1021/co400075z

DO - 10.1021/co400075z

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AN - SCOPUS:84885578571

SN - 2156-8952

VL - 15

SP - 551

EP - 555

JO - ACS Combinatorial Science

JF - ACS Combinatorial Science

IS - 10

ER -

One-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles via A multicomponent [4 + 1] cycloaddition reaction

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