TY - JOUR
T1 - One-Pot Synthesis of Unsymmetrical Bis-Heterocycles
T2 - Benzimidazole-, Benzoxazole-, and Benzothiazole-Linked Thiazolidines
AU - Lu, Hsueh Yuan
AU - Barve, Indrajeet J.
AU - Selvaraju, Manikandan
AU - Sun, Chung Ming
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/11/22
Y1 - 2019/11/22
N2 - A one-pot, three-component synthesis of benzimidazole-linked thiazolidines from 2-cyanomethyl benzimidazole, iso-, isothio-, or isoselenocyanates and 1,2-dichloroethane is reported. Isolation of the key intermediate formed during the course of the reaction validates its mechanistic pathway. Under the same reaction conditions, benzimidazole-linked/fused thiazinanes were obtained when 1,3-dichloropropane or diiodomethane was used.
AB - A one-pot, three-component synthesis of benzimidazole-linked thiazolidines from 2-cyanomethyl benzimidazole, iso-, isothio-, or isoselenocyanates and 1,2-dichloroethane is reported. Isolation of the key intermediate formed during the course of the reaction validates its mechanistic pathway. Under the same reaction conditions, benzimidazole-linked/fused thiazinanes were obtained when 1,3-dichloropropane or diiodomethane was used.
KW - benzimidazoles
KW - combinatorial chemistry
KW - microwave irradiation
KW - molecular diversity
KW - one-pot reaction
KW - three-component synthesis
UR - http://www.scopus.com/inward/record.url?scp=85076767024&partnerID=8YFLogxK
U2 - 10.1021/acscombsci.9b00161
DO - 10.1021/acscombsci.9b00161
M3 - Article
C2 - 31756080
AN - SCOPUS:85076767024
SN - 2156-8952
VL - 22
SP - 42
EP - 48
JO - ACS Combinatorial Science
JF - ACS Combinatorial Science
IS - 1
ER -