One-pot synthesis of triazoloquinazolinones via copper- catalyzed tandem click and intramolecular C-H amidation

A novel and highly efficient copper-catalyzed tandem synthesis of triazoloquinazolinones is explored. The synthetic strategy involves a sequential one-pot click reaction followed by aerobic intramolecular C-H amidation. Two distinct and important transformations were carried out in one-pot by employing a single cost-effective copper catalyst. The milder, rapid and ligand-free reaction conditions as well as a broader substrate scope are the salient features of this novel protocol.