Oligonucleotides as 'bio-solvent' for in situ extraction and functionalisation of carbon nanoparticles

Yu Cheng Chen, Cheng Che Wen, Ian Liau, You-Zung Hsieh, Hsin-Yun Hsu*


研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)


A simple yet novel one-pot approach is developed to prepare carbon nanoparticles with diameters of ∼2 nm and modified by oligonucleotides. We use single-stranded deoxyribonucleic acid (ssDNA), which serves as a unique 'bio-solvent' for carbon nanoparticle (CNP) preparation and as a target molecule for functionalisation. Proposed interactions relevant to the stabilisation of the final oligonucleotide-CNP complex include π-π stacking and π-HN bonding with sp2 carbon atoms on the CNP surface. Furthermore, oligonucleotide-enriched CNPs can be readily extracted within seconds from a crude mixture of single-walled carbon nanotubes (SWCNTs) without any need for post-synthesis chemical modification. The established CNPs are biocompatible, possess intrinsic fluorescence, and do not result in the undesirable photobleaching effect, rendering them potential candidates for in vivo biological applications.

頁(從 - 到)4100-4107
期刊Journal of Materials Chemistry B
出版狀態Published - 23 4月 2014


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