Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells

Samina Salim*, Mohammad Asghar, Manish Taneja, Iiris Hovatta, Yuh Lin Wu, Kaustuv Saha, Nada Sarraj, Brian Hite

*此作品的通信作者

研究成果: Article同行評審

17 引文 斯高帕斯(Scopus)

摘要

Regulator of G-protein signaling protein (RGS)-2 is a modulator of anxiety and dysregulation of oxidative stress is implicated in anxiety. Also, RGS2 expression is reported to be induced by oxidative stress. Thus, if oxidative stress induces RGS2 expression and lack of RGS2 causes anxiety, then mechanisms that link RGS2 and oxidative stress potentially critical to anxiety must be revealed. Our study is the first to suggest role of RGS2 in regulation of enzymes involved in antioxidant defense namely glyoxalase-1 and glutathione reductase-1 via activation of p38 MAPK and PKC pathways in an Sp-1 dependent manner.

原文English
頁(從 - 到)1375-1381
頁數7
期刊FEBS Letters
585
發行號9
DOIs
出版狀態Published - 6 5月 2011

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