Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics

Angela J. Wright, Susan E. Matthews, Wolfgang B. Fischer, Paul D. Beer*

*此作品的通信作者

研究成果: Article同行評審

74 引文 斯高帕斯(Scopus)

摘要

A series of novel resorcin[4]arenes with extended π systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.

原文English
頁(從 - 到)3474-3481
頁數8
期刊Chemistry - A European Journal
7
發行號16
DOIs
出版狀態Published - 17 8月 2001

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