Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics

Angela J. Wright; Susan E. Matthews; Wolfgang B. Fischer; Paul D. Beer

doi:10.1002/1521-3765(20010817)7:16<3474::AID-CHEM3474>3.0.CO;2-6

Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics

Angela J. Wright, Susan E. Matthews, Wolfgang B. Fischer, Paul D. Beer^*

^*此作品的通信作者

生醫光電研究所

研究成果: Article › 同行評審

73 引文斯高帕斯（Scopus）

摘要

A series of novel resorcin[4]arenes with extended π systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K⁺ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K⁺/Na⁺ selectivity.

原文	English
頁（從 - 到）	3474-3481
頁數	8
期刊	Chemistry - A European Journal
卷	7
發行號	16
DOIs	https://doi.org/10.1002/1521-3765(20010817)7:16<3474::AID-CHEM3474>3.0.CO;2-6
出版狀態	Published - 17 8月 2001

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10.1002/1521-3765(20010817)7:16<3474::AID-CHEM3474>3.0.CO;2-6

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title = "Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics",

abstract = "A series of novel resorcin[4]arenes with extended π systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.",

keywords = "Alkali metals, Ion channels, Ionophores, Planar lipid bilayer, Resorcin[4]arenes",

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year = "2001",

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AU - Matthews, Susan E.

AU - Fischer, Wolfgang B.

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N2 - A series of novel resorcin[4]arenes with extended π systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.

AB - A series of novel resorcin[4]arenes with extended π systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.

KW - Alkali metals

KW - Ion channels

KW - Ionophores

KW - Planar lipid bilayer

KW - Resorcin[4]arenes

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DO - 10.1002/1521-3765(20010817)7:16<3474::AID-CHEM3474>3.0.CO;2-6

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JF - Chemistry - A European Journal

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Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics

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