Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation

Guangyao Kong, Juan Du, Yangang Liu, Benjamin Meline, Yuan I. Chang, Erik A. Ranheim, Jinyong Wang, Jing Zhang*

*此作品的通信作者

研究成果: Article同行評審

26 引文 斯高帕斯(Scopus)

摘要

Background: Endogenous oncogenic Kras induces a highly penetrant acute T-cell lymphoblastic leukemia/lymphoma (T-ALL). Results: Up-regulation of NOTCH1 signaling, through either overexpression of surface NOTCH1 or acquired gain-of-function mutations, is involved in both T-ALL initiation and progression. Conclusion: Notch1 mutations contribute to leukemogenic transformation of normal T-cells. Significance: Our data provide a rationale to target both NOTCH1 and RAS signaling for T-ALL treatment.

原文English
頁(從 - 到)18219-18227
頁數9
期刊Journal of Biological Chemistry
288
發行號25
DOIs
出版狀態Published - 21 6月 2013

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