Nonparametric multiple test procedures for dose finding

Show Li Jan*, Gwowen Shieh

*此作品的通信作者

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

We consider identifying the minimum effective dose (MED) in a one-way layout, where the MED is denned to be the lowest dose level that is more effective than the zero-dose control. Proposed herein are two rank-based nonparametric step-down closed testing procedures that do not make order assumptions on the dose-response relationship. The corresponding p-value for the estimated MED is computed. A numerical example is given to illustrate the proposed tests. Finally, the results of a Monte Carlo study of the relative error rate and power performances are reported.

原文English
頁(從 - 到)1021-1037
頁數17
期刊Communications in Statistics Part B: Simulation and Computation
33
發行號4
DOIs
出版狀態Published - 15 2月 2004

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