摘要
We consider identifying the minimum effective dose (MED) in a one-way layout, where the MED is denned to be the lowest dose level that is more effective than the zero-dose control. Proposed herein are two rank-based nonparametric step-down closed testing procedures that do not make order assumptions on the dose-response relationship. The corresponding p-value for the estimated MED is computed. A numerical example is given to illustrate the proposed tests. Finally, the results of a Monte Carlo study of the relative error rate and power performances are reported.
原文 | English |
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頁(從 - 到) | 1021-1037 |
頁數 | 17 |
期刊 | Communications in Statistics Part B: Simulation and Computation |
卷 | 33 |
發行號 | 4 |
DOIs | |
出版狀態 | Published - 15 2月 2004 |