Nonequilibrium gating of CFTR on an equilibrium Theme

Kang Yang Jih*, Tzyh Chang Hwang

*此作品的通信作者

研究成果: Review article同行評審

32 引文 斯高帕斯(Scopus)

摘要

Malfunction of cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ABC protein superfamily that functions as an ATP-gated chloride channel, causes the lethal genetic disease, cystic fibrosis. This review focuses on the most recent findings on the gating mechanism of CFTR. Potential clinical relevance and implications to ABC transporter function are also discussed.

原文English
頁(從 - 到)351-361
頁數11
期刊Physiology
27
發行號6
DOIs
出版狀態Published - 1 12月 2012

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