Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation

Hui Chuan Yu; Chen Si Lin; Wei Tien Tai; Chun Yu Liu; Chung Wai Shiau; Kuen Feng Chen

doi:10.1074/jbc.M112.446385

Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation

Hui Chuan Yu, Chen Si Lin, Wei Tien Tai, Chun Yu Liu, Chung Wai Shiau, Kuen Feng Chen^*

^*此作品的通信作者

研究成果: Article › 同行評審

93 引文斯高帕斯（Scopus）

摘要

Background: Nilotinib, an approved drug for leukemia, has been investigated in HCC. Results: Nilotinib induced autophagy in HCC cell lines, including PLC5, Huh-7, and Hep3B. Conclusion: Nilotinib-induced AMPK activation and subsequent autophagy is a major mode of action of nilotinib in HCC. Significance: Elucidating the mechanisms by which nilotinib works on HCC is fundamental to develop the new treatment for HCC.

原文	English
頁（從 - 到）	18249-18259
頁數	11
期刊	Journal of Biological Chemistry
卷	288
發行號	25
DOIs	https://doi.org/10.1074/jbc.M112.446385
出版狀態	Published - 21 6月 2013

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title = "Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation",

abstract = "Background: Nilotinib, an approved drug for leukemia, has been investigated in HCC. Results: Nilotinib induced autophagy in HCC cell lines, including PLC5, Huh-7, and Hep3B. Conclusion: Nilotinib-induced AMPK activation and subsequent autophagy is a major mode of action of nilotinib in HCC. Significance: Elucidating the mechanisms by which nilotinib works on HCC is fundamental to develop the new treatment for HCC.",

author = "Yu, {Hui Chuan} and Lin, {Chen Si} and Tai, {Wei Tien} and Liu, {Chun Yu} and Shiau, {Chung Wai} and Chen, {Kuen Feng}",

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AU - Yu, Hui Chuan

AU - Lin, Chen Si

AU - Tai, Wei Tien

AU - Liu, Chun Yu

AU - Shiau, Chung Wai

AU - Chen, Kuen Feng

PY - 2013/6/21

Y1 - 2013/6/21

N2 - Background: Nilotinib, an approved drug for leukemia, has been investigated in HCC. Results: Nilotinib induced autophagy in HCC cell lines, including PLC5, Huh-7, and Hep3B. Conclusion: Nilotinib-induced AMPK activation and subsequent autophagy is a major mode of action of nilotinib in HCC. Significance: Elucidating the mechanisms by which nilotinib works on HCC is fundamental to develop the new treatment for HCC.

AB - Background: Nilotinib, an approved drug for leukemia, has been investigated in HCC. Results: Nilotinib induced autophagy in HCC cell lines, including PLC5, Huh-7, and Hep3B. Conclusion: Nilotinib-induced AMPK activation and subsequent autophagy is a major mode of action of nilotinib in HCC. Significance: Elucidating the mechanisms by which nilotinib works on HCC is fundamental to develop the new treatment for HCC.

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VL - 288

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JO - Journal of Biological Chemistry

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ER -

Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation

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