Neutron capture nuclei-containing carbon nanoparticles for destruction of cancer cells

Kuo Chu Hwang*, Po Dong Lai, Chi Shiun Chiang, Pei Jen Wang, Chiun-Jye Yuan

*此作品的通信作者

研究成果: Article同行評審

28 引文 斯高帕斯(Scopus)

摘要

HeLa cells were incubated with neutron capture nuclei (boron-10 and gadolinium)-containing carbon nanoparticles, followed by irradiation of slow thermal neutron beam. Under a neutron flux of 6 × 1011 n/cm2 (or 10 min irradiation at a neutron flux of 1 × 109 n/cm2 s), the percentages of acute cell death at 8 h after irradiation are 52, 55, and 28% for HeLa cells fed with BCo@CNPs, GdCo@CNPs, and Co@CNPs, respectively. The proliferation capability of the survived HeLa cells was also found to be significantly suppressed. At 48 h after neutron irradiation, the cell viability further decreases to ~35 ± 5% as compared to the control set receiving the same amount of neutron irradiation dose but in the absence of carbon nanoparticles. This work demonstrates " proof-of-concept" examples of neutron capture therapy using 10B-, 157Gd-, and 59Co-containing carbon nanoparticles for effective destruction of cancer cells. It will also be reported the preparation and surface functionalization of boron or gadolinium doped core-shell cobalt/carbon nanoparticles (BCo@CNPs, GdCo@CNPs and Co@CNPs) using a modified DC pulsed arc discharge method, and their characterization by various spectroscopic measurements, including TEM, XRD, SQUID, FT-IR, etc. Tumor cell targeting ability was introduced by surface modification of these carbon nanoparticles with folate moieties.

原文English
頁(從 - 到)8419-8425
頁數7
期刊Biomaterials
31
發行號32
DOIs
出版狀態Published - 1 11月 2010

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