Network analysis for investigating functional connectivity in major depression disorder: A functional magnetic images (fMRI) study

Shin Teng, Po Shan Wang, Yuan Lin Liao, Tzu Chen Yeh, Jen Chuen Hsieh, Yu Te Wu*

*此作品的通信作者

研究成果: Conference contribution同行評審

摘要

Major depressive disorder (MDD) is a common mental disorder characterized by a pervasive low mood. The aim of this study is to investigate the difference of network properties of functional network derived from functional magnetic resonance imaging (fMRI) between the healthy subjects and the patients with major depression disorder. The functional MR images were acquired from 13 healthy subjects and 19 patients with major depression disorder. All images of each subject were parcellated into cortical and sub-cortical regions which were defined as the nodes of the network. The functional relations between these regions were estimated by the timefrequency cross mutual information (TFCMI) followed by a thresholding to construct a set of undirected graphs. Our findings indicated that the MDD patients presented lower degree, strength and cliquishness of connections, whereas longer mean path length in the brain network. This suggested the reduced efficiency of the brain network for MDD patients. In addition, the network properties of MDD patients were altered significantly in some regions in the frontal lobes and limbic system which were in good agreement with the dysfunction connectivity reported by the previous literatures in the study of major depression disorder.

原文English
主出版物標題World Congress on Medical Physics and Biomedical Engineering
主出版物子標題Diagnostic Imaging
發行者Springer Verlag
頁面932-935
頁數4
版本2
ISBN(列印)9783642038785
DOIs
出版狀態Published - 2009
事件World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging - Munich, Germany
持續時間: 7 9月 200912 9月 2009

出版系列

名字IFMBE Proceedings
號碼2
25
ISSN(列印)1680-0737

Conference

ConferenceWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging
國家/地區Germany
城市Munich
期間7/09/0912/09/09

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