NCNEt: Deep Learning Network Models for Predicting Function of Non-coding DNA

Hanyu Zhang, Che Lun Hung*, Meiyuan Liu, Xiaoye Hu, Yi Yang Lin

*此作品的通信作者

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

The human genome consists of 98.5% non-coding DNA sequences, and most of them have no known function. However, a majority of disease-associated variants lie in these regions. Therefore, it is critical to predict the function of non-coding DNA. Hence, we propose the NCNet, which integrates deep residual learning and sequence-to-sequence learning networks, to predict the transcription factor (TF) binding sites, which can then be used to predict non-coding functions. In NCNet, deep residual learning networks are used to enhance the identification rate of regulatory patterns of motifs, so that the sequence-to-sequence learning network may make the most out of the sequential dependency between the patterns. With the identity shortcut technique and deep architectures of the networks, NCNet achieves significant improvement compared to the original hybrid model in identifying regulatory markers.

原文English
文章編號432
期刊Frontiers in Genetics
10
發行號MAY
DOIs
出版狀態Published - 2019

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