Nanowire Field-Effect Transistor-Based Biosensors as a Tool for Life Science

Electrical biosensors based on silicon nanowire field-effect
transistors (SiNW-FETs) have attracted enormous interest in the
biosensing field. SiNW-FETs have proven to be significant and
efficient in detecting diverse biomolecular species with the
advantages of high probing sensitivity, target selectivity, real-time recording, and label-free detection. In recent years, significant advances in biosensors have been achieved, particularly for
cellular investigation and biomedical diagnosis. In this paper, we will report on the recent achievements with SiNW-FET biosensors for the fast screening of protein-protein interaction and sensitive detection of neurotransmitters release from live cells. Despite these remarkable achievements, certain improvements remain necessary
in the device performance and clinical applications of FET-based
biosensors; thus, several prospects about the future development of
nanowire transistor-based instruments for biosensing employments are discussed at the end of this paper.