Nanoplasmon coupled intracellular optical resonance excitation for ultrasensitive 3D fluorescence cell imaging

Manas Ranjan Gartia, Austin Hsiao, Mayandi Sivaguru, Yi-Chun Chen, G. Logan Liu*

*此作品的通信作者

研究成果: Conference contribution同行評審

摘要

We have created an enhanced cell-imaging platform for 3D confocal fluorescence cell imaging where fluorescence sensitivity is amplified for more than 100 folds especially for cell membrane and cytoplasm. The observed unprecedented three-dimensional fluorescence intensity enhancement on the entire cell microstructure including cell membrane 10 μm above the substrate surface is attributed to a novel far field enhancement mechanism, nanoplasmon coupled optical resonance excitation (CORE) mechanism which permits enhanced surface plasmon on the substrate being evanescently coupled to Whispering Gallery mode optical resonance inside the spheroidal cell membrane microcavity. Theoretical model of the hypothesis is explained using coupled mode theory. In addition, preliminary result has been provided for the observation of early stage of transfection in a cancer cell.

原文English
主出版物標題Biosensing and Nanomedicine IV
DOIs
出版狀態Published - 19 十月 2011
事件Biosensing and Nanomedicine IV - San Diego, CA, United States
持續時間: 21 八月 201123 八月 2011

出版系列

名字Proceedings of SPIE - The International Society for Optical Engineering
8099
ISSN(列印)0277-786X

Conference

ConferenceBiosensing and Nanomedicine IV
國家/地區United States
城市San Diego, CA
期間21/08/1123/08/11

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