Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review

Tsai Chin Cheng, Shou Hsien Huang, Chung Lan Kao, Po Cheng Hsu*

*此作品的通信作者

研究成果: Review article同行評審

4 引文 斯高帕斯(Scopus)

摘要

Muscle wasting, known to develop in patients with chronic kidney disease (CKD), is a deleterious consequence of numerous complications associated with deteriorated renal function. Muscle wasting in CKD mainly involves dysregulated muscle protein metabolism and impaired muscle cell regeneration. In this narrative review, we discuss the cardinal role of the insulin‐like growth factor 1 and myostatin signaling pathways, which have been extensively investigated using animal and human studies, as well as the emerging concepts in microRNA‐ and gut microbiota-mediated regulation of muscle mass and myogenesis. To ameliorate muscle loss, therapeutic strategies, including nutritional support, exercise programs, pharmacological interventions, and physical modalities, are being increasingly developed based on advances in understanding its underlying pathophysiology.

原文English
文章編號6047
期刊International Journal Of Molecular Sciences
23
發行號11
DOIs
出版狀態Published - 1 6月 2022

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