Multiphoton and confocal imaging of precisely cut oral cancer tumor sections for personalized medicine

Shu Jen Chiang*, Po Hang Tseng, Hsu Cheng Huang, Shih Chi Chen, Shean-Jen Chen, Mei Chun Lin, Pei Jen Lou, Chen Yuan Dong

*此作品的通信作者

研究成果: Conference contribution同行評審

摘要

Traditionally, testing of therapeutic agents uses two-dimensional cell cultures which does not recapitulate the complex, three-dimensional architecture of tissues. In the case of cancer drug development, immunotherapy (IT) emerged as an effective treatment strategy for the patients who respond to therapy. However, the overall patient response rate for immunotherapy is around 25%. Therefore, there is a need to develop more effective drug testing platform for cancer patients. In this work, we develop three-dimensional tissue cultures of human oral cancer slices. We observed the growth dynamics of the tissue sections for up to 28 days. Their viability over extended periods suggest that the tissue sections may be used for personalized drug testing.

原文English
主出版物標題Multiphoton Microscopy in the Biomedical Sciences XX
編輯Ammasi Periasamy, Peter T. C. So, Karsten Konig, Karsten Konig
發行者SPIE
頁數5
ISBN(電子)9781510632516
DOIs
出版狀態Published - 21 二月 2020
事件Multiphoton Microscopy in the Biomedical Sciences XX 2020 - San Francisco, United States
持續時間: 2 二月 20204 二月 2020

出版系列

名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE
11244
ISSN(列印)1605-7422

Conference

ConferenceMultiphoton Microscopy in the Biomedical Sciences XX 2020
國家/地區United States
城市San Francisco
期間2/02/204/02/20

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