Multi-wavelength fluorescence tomography

Tiffany C. Kwong, Pei An Lo, Jaedu Cho, Farouk Nouizi, Huihua K. Chiang, Chang Seok Kim, Gultekin Gulsen

研究成果: Conference contribution同行評審


The strong scattering and absorption of light in biological tissue makes it challenging to model the propagation of light, especially in deep tissue. This is especially true in fluorescent tomography, which aims to recover the internal fluorescence source distribution from the measured light intensities on the surface of the tissue. The inherently ill-posed and underdetermined nature of the inverse problem along with strong tissue scattering makes Fluorescence Tomography (FT) extremely challenging. Previously, multispectral detection fluorescent tomography (FT) has been shown to improve the image quality of FT by incorporating the spectral filtering of biological tissue to provide depth information to overcome the inherent absorption and scattering limitations. We investigate whether multi-wavelength fluorescent tomography can be used to distinguish the signals from multiple fluorophores with overlapping fluorescence spectrums using a unique near-infrared (NIR) swept laser. In this work, a small feasibility study was performed to see whether multi-wavelength FT can be used to detect subtle shifts in the absorption spectrum due to differences in fluorophore microenvironment.

主出版物標題Design and Quality for Biomedical Technologies IX
編輯Rongguang Liang, Ramesh Raghavachari
出版狀態Published - 2016
事件Design and Quality for Biomedical Technologies IX - San Francisco, United States
持續時間: 13 2月 201614 2月 2016


名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE


ConferenceDesign and Quality for Biomedical Technologies IX
國家/地區United States
城市San Francisco


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