MRI-compatible Nb-60Ta-2Zr alloy used for vascular stents: Haemocompatibility and its correlation with protein adsorption

Xiu Mei Li, Hui Zhe Li, Shao Ping Wang, Hsun Miao Huang, Her Hsiung Huang, Hong Jun Ai*, Jian Xu

*此作品的通信作者

研究成果: Article同行評審

18 引文 斯高帕斯(Scopus)

摘要

Nb-60Ta-2Zr is a newly developed MRI-compatible alloy used for vascular stents. In this work, its haemocompatibility was investigated, including platelet adhesion (lactate dehydrogenase activity), platelet activation (P-selectin expression), coagulation and haemolysis. For comparison, parallel assessments for these factors were performed for the niobium, tantalum, 316L stainless steel (316L SS) and L605 Co-Cr alloy (L605). In addition, albumin and fibrinogen were selected to examine the correlation of protein adsorption with platelet adhesion and metal surface properties. The propensity for platelet adhesion and activation on the Nb-60Ta-2Zr alloy was at nearly the same level as that for Nb and Ta but was slightly less than those of 316L SS and L605. The mitigated platelet adhesion and activation of the Nb-60Ta-2Zr alloy is associated with its decreased adsorption of fibrinogen. The Nb-60Ta-2Zr alloy has a longer clotting time and exhibits significantly superior thromboresistance than 316L SS and L605. Moreover, the haemolysis rate of the Nb-60Ta-2Zr alloy satisfies the bio-safety requirement of the ISO 10993-4 standard. The favourable haemocompatiblity of the Nb-60Ta-2Zr alloy provides evidence of its good biocompatibility and of its suitability as a candidate stent material.

原文English
頁(從 - 到)385-395
頁數11
期刊Materials Science and Engineering C
42
DOIs
出版狀態Published - 1 9月 2014

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