Monitoring of Vascular Response to Peri-Infarct Depolarization (PID) in Photothrombotic Stroke Animal Model

Peri-infarct depolarization (PID) is abnormal transient depolarization waves slowly propagating in the cortex and confined in the ipsi-lesional cortex in accompanied with dramatic cerebral blood flow change. Ultrafast Doppler is a quantitative imaging method to investigate both CBF and CBV in a high spatiotemporal resolution and to measure the hemodynamic response of penetrating vessels in the cortex. In this study, the hemodynamics of cortical vessels during stroke-induced PID was monitored by the dynamic ultrafast Doppler under the animal model of photothrombotic stroke. The propagating PID-induced blood flow change (ΔCBV) initiated from the center of the stoke induction site and propagated outward in the right cortex. This study, for the first time, introduces a novel platform to demonstrate that dynamic ultrafast Doppler is feasible to monitor PID during acute stroke.