Molecular investigation and diagnosis of lung cancer via the network-based biomarker

Yu-Chao Wang*, Bor Sen Chen

*此作品的通信作者

研究成果: Conference contribution同行評審

摘要

Lung cancer is the leading cause of cancer deaths worldwide. Many studies have investigated the carcinogenic process and identified the biomarkers for signature classification. However, to the best of knowledge, there is no satisfactory network-based method for carcinogenesis characterization and diagnosis from the systems perspective. In this study, a systems biology approach, which integrated microarray gene expression profiles and protein-protein interaction information, was proposed to develop a network-based biomarker for molecular investigation and diagnosis of lung cancer. A total of 40 significant proteins are identified with carcinogenesis relevance values (CRVs) to gain an insight into the network mechanism of lung carcinogenesis. In addition, the network-based biomarker is also acted as the diagnostic tool, demonstrated to be effective to diagnose the smokers with lung cancer.

原文English
主出版物標題ASCC 2011 - 8th Asian Control Conference - Final Program and Proceedings
頁面488-493
頁數6
出版狀態Published - 15 5月 2011
事件8th Asian Control Conference, ASCC 2011 - Kaohsiung, 台灣
持續時間: 15 5月 201118 5月 2011

出版系列

名字ASCC 2011 - 8th Asian Control Conference - Final Program and Proceedings

Conference

Conference8th Asian Control Conference, ASCC 2011
國家/地區台灣
城市Kaohsiung
期間15/05/1118/05/11

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