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Molecular imaging of active mutant L858R EGF receptor (EGFR) kinase-expressing nonsmall cell lung carcinomas using PET/CT
Hsin Hsien Yeh
, Kazuma Ogawa
, Julius Balatoni
, Uday Mukhapadhyay
, Asutosh Pal
, Carlos Gonzalez-Lepera
, Aleksandr Shavrin
, Suren Soghomonyan
, Leo Flores
, Daniel Young
, Andrei Y. Volgin
, Amer M. Najjar
, Victor Krasnykh
, William Tong
, Mian M. Alauddin
, Juri G. Gelovani
腦科學研究中心
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引文 斯高帕斯(Scopus)
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Keyphrases
Active Site mutant
100%
Receptor-interacting Protein Kinase 1 (RIPK1)
100%
Non-small Cell Lung Cancer (NSCLC)
100%
EGF Receptor
100%
L858R
100%
Molecular Imaging
100%
Positron Emission Tomography-computed Tomography (PET-CT)
100%
Ethoxy
55%
Xenograft
33%
Kinase Domain
22%
Gefitinib
22%
Gene Sequencing
11%
Therapeutic Agents
11%
Tumor
11%
Amino
11%
Tumor-bearing Mice
11%
Signaling Pathway
11%
Imaging Approach
11%
Acrylamide
11%
H1975
11%
EGF Receptor Signaling
11%
Safety Profile
11%
Efficacy Profile
11%
Therapeutic Approaches
11%
Quinazoline
11%
Iressa
11%
Kinase Inhibitor
11%
Erlotinib
11%
Similarity Structure
11%
Radiotracer
11%
Novel Diagnostics
11%
Novel Biomarkers
11%
Enhanced Selectivity
11%
H441
11%
Activating mutation
11%
Diagnostic Imaging
11%
Personalized Therapy
11%
Increased Safety
11%
L858R/T790M
11%
T790M mutation
11%
Small Molecule Inhibitors
11%
Sequencing Studies
11%
Biomarker Imaging
11%
Improved Efficacy
11%
Medicine and Dentistry
Non Small Cell Lung Cancer
100%
Epidermal Growth Factor Receptor
100%
Phosphotransferase
100%
Molecular Imaging
100%
Positron Emission Tomography-Computed Tomography
100%
Fluorine-18
50%
Xenograft
30%
Gefitinib
30%
Neoplasm
20%
Polyethylene Terephthalate
20%
Gene Sequence
10%
Biological Marker
10%
Personalized Medicine
10%
Quinazoline
10%
Diagnostic Imaging
10%
Erlotinib
10%
Phosphotransferase Inhibitor
10%
Radioactive Tracer
10%
Epidermal Growth Factor Receptor Kinase Inhibitor
10%
Therapeutic Agent
10%
Cell Signaling Pathway
10%
Acrylamide
10%
Pharmacology, Toxicology and Pharmaceutical Science
Non Small Cell Lung Cancer
100%
Phosphotransferase
100%
Epidermal Growth Factor Receptor
100%
Polyethylene Terephthalate
100%
Fluorine 18
50%
Gefitinib
30%
Neoplasm
20%
Epidermal Growth Factor Receptor Kinase Inhibitor
10%
Biological Marker
10%
Quinazoline
10%
Phosphotransferase Inhibitor
10%
Erlotinib
10%
Tracer
10%
Acrylamide
10%
Biochemistry, Genetics and Molecular Biology
Epidermal Growth Factor Receptor
100%
Phosphotransferase
100%
Kinase
100%
Positron Emission Tomography-Computed Tomography
100%
Gefitinib
18%
Gene Sequence
9%
Erlotinib
9%