Molecular Design of Ultrabright Semiconducting Polymer Dots with High NIR-II Fluorescence for 3D Tumor Mapping

Yi Xuan Li, Shih Po Su, Chou Hsun Yang, Ming Ho Liu, Pin Ho Lo, Yi Chen Chen, Chao Ping Hsu, Yi-Jang Lee, Hui-Hua Chiang, Yang-Hsiang Chan*

*此作品的通信作者

研究成果: Article同行評審

10 引文 斯高帕斯(Scopus)

摘要

Fluorescence probes emitting in the second near-infrared (NIR-II, 1000–1700 nm) window with the ability for deep-tissue imaging in mammals herald a new era in surgical methodology. However, the brightness of these NIR-II probes is still far from satisfactory due to their low fluorescence quantum yields (QYs), preventing the observation of high-resolution images such as whole-organ vascular networks in real time. Described here is the molecular engineering of a series of semiconducting polymer dots (Pdots) incorporated with aggregation-induced emission moieties to exhibit the QYs as high as 14% in the NIR-II window. Benefiting from the ultrahigh brightness, a 1400 nm long-pass filter is utilized to realize in vivo 3D tumor mapping in mice. To further understand how the geometrical and electron structures of the semiconducting polymers affect their optical properties, the in-depth and thorough density-functional theory calculations are performed to interpret the experimental results. This study lays the groundwork for further molecular design of highly bright NIR-II Pdots.

原文English
文章編號210093
頁(從 - 到)1-10
頁數10
期刊Advanced Healthcare Materials
DOIs
出版狀態E-pub ahead of print - 22 9月 2021

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