Modulation of macrophage differentiation and activation by decoy receptor 3

Yung Chi Chang, Tsui Ling Hsu, Hsi Hsien Lin, Chung Ching Chio, Allen W. Chiu, Nien Jung Chen, Chi Hung Lin, Shie Liang Hsieh*


研究成果: Article同行評審

76 引文 斯高帕斯(Scopus)


Decoy receptor 3 (DcR3) is a soluble receptor of the tumor necrosis factor receptor superfamily and is readily detected in certain cancer patients. Recently, we demonstrated that DcR3.Fc-treated dendritic cells skew T cell responses to a T helper cell type 2 phenotype. In this study, we further asked its ability to modulate CD14+ monocyte differentiation into macrophages induced by macrophage-colony stimulating factor in vitro. We found that DcR3.Fc was able to modulate the expression of several macrophage markers, including CD14, CD16, CD64, and human leukocyte antigen-DR. In contrast, the expression of CD11c, CD36, CD68, and CD206 (mannose receptor) was not affected in the in vitro culture system. Moreover, phagocytic activity toward immune complexes and apoptotic bodies as well as the production of free radicals and proinflammatory cytokines in response to lipopolysaccharide were impaired in DcR3.Fc-treated monocyte-derived macrophages. This suggests that DcR3.Fc might have potent, suppressive effects to down-regulate the host-immune system.

頁(從 - 到)486-494
期刊Journal of Leukocyte Biology
出版狀態Published - 三月 2004


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