Model generation of viral channel forming 2B protein bundles from polio and coxsackie viruses

George Patargias, Thomas Barke, Anthony Watts, Wolfgang B. Fischer

研究成果: Article同行評審

18 引文 斯高帕斯(Scopus)

摘要

2B is a 99 amino acid membrane protein encoded by enteroviruses such as polio and coxsackie viruses with two transmembrane domains. The protein is found to make membranes of infected cells permeable. Using a computational approach which positions the models and assesses stability by molecular dynamics (MD) simulations a putative tetrameric bundle model of 2B is generated. The bundles show a pore lining motif of three lysines followed by a serine. The bundle is discussed in terms of different possible orientations of the helices in the membrane and the consequences this has on the in vivo activity of 2B.

原文English
頁(從 - 到)309-320
頁數12
期刊Molecular Membrane Biology
26
發行號5-7
DOIs
出版狀態Published - 2009

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