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Minocycline accelerates hypoxia-inducible factor-1 alpha degradation and inhibits hypoxia-induced neovasculogenesis through prolyl hydroxylase, von Hippel-Lindau-dependent pathway
Ching Hao Li
,
Po Lin Liao
, Ya Ting Yang
, Shih Hsuan Huang
, Cheng Hui Lin
, Yu Wen Cheng
*
,
Jaw Jou Kang
*
此作品的通信作者
食品安全及健康風險評估研究所
研究成果
:
Article
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同行評審
20
引文 斯高帕斯(Scopus)
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Keyphrases
Hypoxia
100%
Hypoxia-inducible factor-1α (HIF-1α)
100%
Minocycline
100%
Von Hippel-Lindau
100%
Prolyl Hydroxylase
100%
Neovasculogenesis
100%
Cancer Cells
25%
Blood Supply
12%
Endothelial Cells
12%
Tumor
12%
Transcription Factor
12%
Proteasomal Degradation
12%
Tumor Progression
12%
Von Hippel-Lindau Disease
12%
Protein-protein Interaction
12%
Incubation
12%
Tumor Growth
12%
Vascular Endothelial Growth factor-C (VEGF-C)
12%
Matrix metalloproteinase-2 (MMP-2)
12%
Lung Adenocarcinoma Cells
12%
Novel Therapeutic Targets
12%
Enhancement Effect
12%
Primary Cells
12%
Mammalian Target of Rapamycin Pathway
12%
AKT/mammalian Target of Rapamycin
12%
Phosphoinositide 3-kinase (PI3K)
12%
Stress Response
12%
Heat Shock Protein 90 (Hsp90)
12%
Glucose Transporter 1 (GLUT1)
12%
Reporter Expression
12%
Tetracycline
12%
Tumor Angiogenesis
12%
Hypoxia-related Diseases
12%
Tumor Hypoxia
12%
Hypoxia Response Element
12%
Prolyl Hydroxylase Domain 2
12%
Hypoxic Condition
12%
Stress-related Gene Expression
12%
VEGF Secretion
12%
Hypoxia Stress
12%
D-matrix
12%
Pharmacology, Toxicology and Pharmaceutical Science
Hypoxia
100%
Hypoxia Inducible Factor 1
100%
Minocycline
100%
Procollagen Proline 2 Oxoglutarate 4 Dioxygenase
100%
Neoplasm
22%
Tumor Growth
22%
Lung Adenocarcinoma
11%
Transcription Factors
11%
Vasculotropin
11%
Vasculotropin C
11%
Gelatinase A
11%
Phosphatidylinositol 3 Kinase
11%
Mammalian Target of Rapamycin
11%
Glucose Transporter 1
11%
Protein Kinase B
11%
Tetracycline
11%
Von Hippel Lindau Protein
11%
Diseases
11%
Biochemistry, Genetics and Molecular Biology
Hypoxia Inducible Factor 1
100%
Procollagen-Proline Dioxygenase
100%
Tumor Progression
28%
Vascularization
14%
Gene Expression
14%
Transcription Factors
14%
Vascular Endothelial Growth Factor
14%
Protein Interaction
14%
Secretion (Process)
14%
Primary Cell
14%
Mechanistic Target of Rapamycin
14%
Phosphoinositide 3-Kinase
14%
Gelatinase A
14%
MMP2
14%
Angiogenesis
14%
Protein Kinase B
14%
Response Element
14%
Vascular Endothelial Growth Factor C
14%
Hsp90
14%
Glucose Transporter
14%