TY - JOUR
T1 - Migraine is a risk factor for sudden sensorineural hearing loss
T2 - A nationwide population-based study
AU - Chu, Chia Huei
AU - Liu, Chia Jen
AU - Fuh, Jong Ling
AU - Shiao, An Suey
AU - Chen, Tzeng Ji
AU - Wang, Shuu Jiun
N1 - Funding Information:
This study was supported in part by grants from the Taiwan National Science Council (100-2314-B-010-019-MY2, 100-2314-B-010-018-MY3), Taipei Veterans General Hospital (VGHUST101-G7-1-1, V101C-106, V101E7-003), NSC support for the Center for Dynamical Biomarkers and Translational Medicine, National Central University, Taiwan (NSC 100-2911-I-008-001), Brain Research Center, National Yang-Ming University and a grant from Ministry of Education, Aim for the Top University Plan.
PY - 2013/1
Y1 - 2013/1
N2 - Background: The pathophysiology of idiopathic sudden sensorineural hearing loss (SSNHL) is poorly understood. Few case reports have proposed a possible link between migraine and SSNHL. Objectives: This study aimed to explore the risk of idiopathic SSNHL in patients with migraine in a nationwide, populationbased cohort study. Methods: We identified patients with migraine from the Taiwan National Health Insurance Research Database (NHIRD) between 2000 and 2009. Each migraine patient was matched with four randomly selected subjects without migraine for age, sex, and comorbidities. Both cohorts were followed up until the end of 2009. We compared the incidence rates of SSNHL in the two cohorts and identified the risk factors. Results: A total of 10,280 migraine patients and 41,120 matched controls were enrolled with a median follow-up of five years. The migraine cohort had a greater risk of developing SSNHL than the matched cohort (81.6 vs. 45.7 per 100,000 person-years, incidence rate ratio (IRR)=1.8; 95% confidence interval (CI) 1.222.61, p=0.002). The Cox proportional hazards analysis revealed that among migraine subjects, comorbidity with hypertension was associated with a trend of developing SSNHL (hazard ratio (HR)=1.92, 95% CI 0.973.79, p=0.06). Conclusions: This population-based study demonstrates that migraine is associated with an increased risk of idiopathic SSNHL, which, however, is a rare condition.
AB - Background: The pathophysiology of idiopathic sudden sensorineural hearing loss (SSNHL) is poorly understood. Few case reports have proposed a possible link between migraine and SSNHL. Objectives: This study aimed to explore the risk of idiopathic SSNHL in patients with migraine in a nationwide, populationbased cohort study. Methods: We identified patients with migraine from the Taiwan National Health Insurance Research Database (NHIRD) between 2000 and 2009. Each migraine patient was matched with four randomly selected subjects without migraine for age, sex, and comorbidities. Both cohorts were followed up until the end of 2009. We compared the incidence rates of SSNHL in the two cohorts and identified the risk factors. Results: A total of 10,280 migraine patients and 41,120 matched controls were enrolled with a median follow-up of five years. The migraine cohort had a greater risk of developing SSNHL than the matched cohort (81.6 vs. 45.7 per 100,000 person-years, incidence rate ratio (IRR)=1.8; 95% confidence interval (CI) 1.222.61, p=0.002). The Cox proportional hazards analysis revealed that among migraine subjects, comorbidity with hypertension was associated with a trend of developing SSNHL (hazard ratio (HR)=1.92, 95% CI 0.973.79, p=0.06). Conclusions: This population-based study demonstrates that migraine is associated with an increased risk of idiopathic SSNHL, which, however, is a rare condition.
KW - Migraine
KW - sudden sensorineural hearing loss
UR - http://www.scopus.com/inward/record.url?scp=84871582104&partnerID=8YFLogxK
U2 - 10.1177/0333102412468671
DO - 10.1177/0333102412468671
M3 - Article
C2 - 23197354
AN - SCOPUS:84871582104
SN - 0333-1024
VL - 33
SP - 80
EP - 86
JO - Cephalalgia
JF - Cephalalgia
IS - 2
ER -