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Midostaurin Modulates Tumor Microenvironment and Enhances Efficacy of Anti-PD-1 against Colon Cancer
Cheng Ta Lai
, Chih Wen Chi
, Shu Hua Wu
, Hui Ru Shieh
,
Jiin Cherng Yen
*
, Yu Jen Chen
*
*
此作品的通信作者
藥理學研究所
醫學系藥理學科
研究成果
:
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同行評審
19
引文 斯高帕斯（Scopus）
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Keyphrases
Tumor Microenvironment
100%
Colon Cancer
100%
Anti-PD-1
100%
Midostaurin
100%
Protein Expression
33%
FMS-like Tyrosine Kinase 3 (FLT3)
33%
CT26
22%
Colorectal Adenocarcinoma Cells
22%
Programmed Death-ligand 1 (PD-L1)
22%
T-REX
22%
Clinical Treatment
11%
Tumor
11%
MRNA Expression
11%
Macrophages
11%
NKG2D
11%
Double Strand
11%
Vascular Endothelial Growth Factor Receptor (VEGFR)
11%
Single-stranded DNA (ssDNA)
11%
Growth Inhibition
11%
M Phase
11%
Cancer Types
11%
Oral Administration
11%
Combination Therapy
11%
Neutrophils
11%
HCT116 Cells
11%
Polyploid
11%
Mouse Spleen
11%
Regulatory T (Treg) Cells
11%
Immune Function
11%
Immunomodulatory Activity
11%
Micronucleus Formation
11%
Interferon Regulatory Factor 3 (IRF3)
11%
SW480 Cells
11%
Splenic Macrophages
11%
Implanted Tumor
11%
C-kit
11%
Stimulator of Interferon Genes (STING)
11%
M1 Macrophages
11%
Acute Myeloid Leukemia
11%
Inflammatory Monocytes
11%
IFNAR1
11%
Anti-programmed Cell Death Protein 1
11%
PKC412
11%
Multinucleation
11%
Cytosolic DNA
11%
Cyclic GMP-AMP Synthase (cGAS)
11%
Tumor Microenvironment Modulation
11%
Cytosolic DNA Sensors
11%
Medicine and Dentistry
Tumor Microenvironment
100%
Colon Carcinoma
100%
Midostaurin
100%
Macrophage
30%
Protein Expression
30%
Neoplasm
20%
Colorectal Carcinoma
20%
Immunotherapy
10%
Cancer
10%
Growth Inhibition
10%
Combination Therapy
10%
Cell Cycle
10%
Mitosis
10%
Immune Function
10%
Cell Cycle M Phase
10%
Acute Myeloid Leukemia
10%
Interferon Regulatory Factor 3
10%
Oral Drug Administration
10%
Programmed Death 1 Receptor
10%
Polyploidy
10%
CD135 Antigen
10%
Micronucleus
10%
Single Stranded DNA
10%
Messenger RNA
10%
Neutrophil
10%
Pharmacology, Toxicology and Pharmaceutical Science
Tumor Microenvironment
100%
Colon Carcinoma
100%
Midostaurin
100%
Neoplasm
20%
Colorectal Carcinoma
20%
Immunotherapy
10%
Combination Therapy
10%
Single Stranded DNA
10%
Interferon Regulatory Factor 3
10%
Acute Myeloid Leukemia
10%
Programmed Death 1 Receptor
10%
CD135 Antigen
10%
Messenger RNA
10%