Microrna-324 in human cancer: Mir-324-5p and mir-324-3p have distinct biological functions in human cancer

Wei Ting Kuo, Shou Yu Yu, Sung Chou Li, Hing Chung Lam, Hong Tai Chang, Wei Shone Chen, Chung Yu Yeh, Syue Fen Hung, Tsai Chi Liu, Tony Wu, Chia Cheng Yu, Kuo Wang Tsai*

*此作品的通信作者

研究成果: Article同行評審

56 引文 斯高帕斯(Scopus)

摘要

MicroRNAs (miRNAs) are small non-coding RNAs that have crucial regulatory functions in carcinogenesis. miR-324-5p and miR-324-3p are generated from the same hairpin RNA structure, however, both are diverse in their direct target genes and expression levels. We report that expression of miR-324-5p and-3p was frequently observed to be either up-regulated or down-regulated, and the selection preference of miR-324 for 5p and 3p arms significantly varied in various types or human cancer. Overexpression of miR-324-5p or-3p suppressed growth and invasion of breast cancer cells. Overexpression of miR-324-5p reduced the growth and invasive abilities of colorectal cancer cells, whereas miR-324-3p suppressed colorectal cancer cell invasion but did not influence cell growth. We conclude that miR-324-5p and miR-324-3p might have distinct biological functions, further complicating the regulatory network in human cancer. Therefore, the arm selection preference of miR-324 may be a method for modulating its function.

原文English
頁(從 - 到)5189-5196
頁數8
期刊Anticancer Research
36
發行號10
DOIs
出版狀態Published - 10月 2016

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