Micro- and nano-fabrication of polymer based microfluidic platforms for BioMEMS applications

Siyi Lai, L. James Lee*, Liyong Yu, Kurt W. Koelling, Marc J. Madou

*此作品的通信作者

研究成果: Conference article同行評審

13 引文 斯高帕斯(Scopus)

摘要

In this paper, we review the approaches developed in our laboratory for polymer-based micro/nanofabrication. For fabrication of microscale features, UV-LIGA (UV-lithography, electroplating, and molding) technology was applied for low-cost mass production. For fabrication of sub-micron or nanoscale features, a novel nano-manufacturing protocol is being developed. The protocol applies a novel nano-lithography imprinting process on an ultra-precision motion-control station. It is capable of economically producing well-defined pores or channels at the nanometer scale on thin polymer layers. The formed thin layers can be used as nano-filters for chemical or bio-separation. They can also be integrated into miniaturized devices for cell immunoprotection or tissue growth. For bonding of polymer-based microfluidic platforms, a novel resin-gas injection-assisted technique has been developed that achieves both bonding and surface modification. This new approach can easily seal microfluidic devices with micron and sub-micron sized channels without blocking the flow path. It can also be used to modify the channel shape, size, and surface characteristics (e.g., hydrophilicity, degree of protein adsorption). By applying the masking technique, local modification of the channel surface can be achieved through cascade resin-gas injection.

原文English
頁(從 - 到)17-27
頁數11
期刊Materials Research Society Symposium - Proceedings
729
DOIs
出版狀態Published - 2002
事件BioMEMS and Bionanotechnology - San Francisco, CA, United States
持續時間: 1 4月 20023 4月 2002

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