METTL3-dependent N⁶-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium

Keyphrases

• Vascular Endothelium 100%
• N6-methyladenosine (m6A) RNA Methylation 100%
• Inflammatory Cascade 100%
• Methyltransferase-like 3 (METTL3) 100%
• KLF4 40%
• Hypermethylation 40%
• NLRP1 30%
• Endothelial Cells 20%
• Knockdown 20%
• Plaque Formation 20%
• Mechanotransduction 20%
• Atherogenesis 20%
• Disturbed Blood Flow 20%
• Carotid Artery 10%
• Blood Flow 10%
• Stress-induced 10%
• Stress Effect 10%
• Phosphorylation 10%
• Overexpression 10%
• Co-immunoprecipitation (co-IP) 10%
• Regulatory Mechanism 10%
• NF-B 10%
• Short Hairpin RNA (shRNA) 10%
• Downstream Targets 10%
• RNA Sequencing (RNA-seq) 10%
• Post-transcriptional 10%
• Branch Point 10%
• NOD-like Receptor Protein 3 (NLRP3) 10%
• YTHDF2 10%
• RNA m6A 10%
• Endothelial Activation 10%
• YTHDF1 10%
• Partial Ligation 10%
• Epitranscriptomics 10%
• M6A Reader 10%
• Hemodynamic Forces 10%
• M6A Methylation 10%
• Mechanism of Atherosclerosis 10%
• Monocyte Adhesion 10%
• Atherosclerotic Risk Factors 10%
• Intra-arterial 10%
• Curvature Points 10%

Biochemistry, Genetics and Molecular Biology

• RNA 100%
• KLF4 100%
• N6-Methyladenosine 100%
• Upregulation 75%
• Blood Flow 75%
• NLRP1 75%
• Hemodynamic 50%
• Downregulation 50%
• Mechanotransduction 50%
• Immunoprecipitation 25%
• Small Hairpin RNA 25%
• RNA Sequence 25%
• Cross-Link 25%
• Methyltransferase 25%
• NLR Family Pyrin Domain containing 3 25%
• RNA Methylation 25%
• Epitranscriptome 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Atherosclerosis 100%
• Kruppel Like Factor 4 100%
• 6 N Methyladenosine 100%
• Atherogenesis 50%
• RNA-Sequencing 25%
• Short Hairpin RNA 25%
• Methyltransferase 25%
• Immunoprecipitation 25%