Metastatic hibernomas in transgenic mice expressing an α-amylase-SV40 T antigen hybrid gene

Niles Fox*, Rosanne Crooke, Lih Hwa S. Hwang, Ueli Schibler, Barbara B. Knowles, Davor Solter

*此作品的通信作者

研究成果: Article同行評審

26 引文 斯高帕斯(Scopus)

摘要

Mice transgenic for a hybrid gene containing the liver promoter of the mouse α-amylase gene (Amy-1a) fused to the SV40 tumor antigen coding region unexpectedly developed malignant brown adipose tissue tumors (malignant hibernomas). Expression of the α-amylase gene had previously been thought to be confined to the liver, parotid, and pancreas; however, analysis of white and brown adipose tissue from nontransgenic mice revealed expression of the endogenous Amy-1a gene in these tissues. Gene constructs driven by the Amy-1a liver promoter thus provide a means of targeting gene expression to the adipocyte cell lineage in transgenic mice. Moreover, the high frequency of metastases in the liver, lungs, spleen, heart, and adrenals of these mice provides an experimental system in which to study the development of disseminated malignancy.

原文English
頁(從 - 到)460-463
頁數4
期刊Science
244
發行號4903
DOIs
出版狀態Published - 1989

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