Metabolic Engineering Design Strategies for Increasing Carbon Fluxes Relevant for Biosynthesis in Cyanobacteria

Arvin Y. Chen, Jason T. Ku, Teresa P. Tsai, Jenny J. Hung, Billy C. Hung, Ethan I. Lan*

*此作品的通信作者

研究成果: Chapter同行評審

摘要

Cyanobacteria are promising microbial cell factories for the direct production of biochemicals and biofuels from CO2. Through genetic and metabolic engineering, they can be modified to produce a variety of both natural and non-natural compounds. To enhance the yield of these products, various design strategies have been developed. In this chapter, strategies used to enhance metabolic fluxes towards common precursors used in biosynthesis, including pyruvate, acetyl-CoA, malonyl-CoA, TCA cycle intermediates, and aromatics, are discussed. Additionally, strategies related to cofactor availability and mixotrophic conditions for bioproduction are also summarize.

原文English
主出版物標題Advances in Biochemical Engineering/Biotechnology
發行者Springer Science and Business Media Deutschland GmbH
頁面105-144
頁數40
DOIs
出版狀態Published - 2023

出版系列

名字Advances in Biochemical Engineering/Biotechnology
183
ISSN(列印)0724-6145
ISSN(電子)1616-8542

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