Metabolic engineering design strategies for increasing acetyl-coa flux

Jason T. Ku, Arvin Y. Chen, Ethan I. Lan*

*此作品的通信作者

研究成果: Review article同行評審

33 引文 斯高帕斯(Scopus)

摘要

Acetyl-CoA is a key metabolite precursor for the biosynthesis of lipids, polyketides, isoprenoids, amino acids, and numerous other bioproducts which are used in various industries. Metabolic engineering efforts aim to increase carbon flux towards acetyl-CoA in order to achieve higher productivities of its downstream products. In this review, we summarize the strategies that have been implemented for increasing acetyl-CoA flux and concentration, and discuss their effects. Furthermore, recent works have developed synthetic acetyl-CoA biosynthesis routes that achieve higher stoichiometric yield of acetyl-CoA from glycolytic substrates.

原文American English
文章編號166
期刊Metabolites
10
發行號4
DOIs
出版狀態Published - 4月 2020

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