MEG-based Classification and Grad-CAM Visualization for Major Depressive and Bipolar Disorders with Semi-CNN

Chun Chih Huang, Intan Low, Chia Hsiang Kao, Chuan Yu Yu, Tung Ping Su, Jen Chuen Hsieh, Yong Sheng Chen, Li Fen Chen*

*此作品的通信作者

研究成果: Conference contribution同行評審

摘要

Major depressive disorder (MDD) and bipolar disorder (BD) are two major mood disorders with partly overlapped symptoms but different treatments. However, their misdiagnosis and mistreatment are common based on the DSM-V criteria, lacking objective and quantitative indicators. This study aimed to develop a novel approach that accurately classifies MDD and BD based on their resting-state magnetoencephalography (MEG) signals during euthymic phases. A revisited 3D CNN model, Semi-CNN, that could automatically detect brainwave patterns in spatial, temporal, and frequency domains was implemented to classify wavelet-transformed MEG signals of normal controls and MDD and BD patients. The model achieved a test accuracy of 96.05% and an average of 95.71% accuracy for 5-fold cross-validation. Furthermore, saliency maps of the model were estimated using Grad-CAM++ to visualize the proposed classification model and highlight disease-specific brain regions and frequencies. Clinical Relevance - Our model provides a stable pipeline that accurately classifies MDD, BD, and healthy individuals based on resting-state MEG signals during the euthymic phases, opening the potential for quantitative and accurate brain-based diagnosis for the highly misdiagnosed MDD/BD patients.

原文English
主出版物標題44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
發行者Institute of Electrical and Electronics Engineers Inc.
頁面1823-1826
頁數4
ISBN(電子)9781728127828
DOIs
出版狀態Published - 2022
事件44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022 - Glasgow, United Kingdom
持續時間: 11 7月 202215 7月 2022

出版系列

名字Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
2022-July
ISSN(列印)1557-170X

Conference

Conference44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
國家/地區United Kingdom
城市Glasgow
期間11/07/2215/07/22

指紋

深入研究「MEG-based Classification and Grad-CAM Visualization for Major Depressive and Bipolar Disorders with Semi-CNN」主題。共同形成了獨特的指紋。

引用此