Mechanism of Function of Viral Channel Proteins and Implications for Drug Development

Wolfgang B. Fischer*, Yi Ting Wang, Christina Schindler, Chin Pei Chen

*此作品的通信作者

研究成果: Chapter同行評審

30 引文 斯高帕斯(Scopus)

摘要

Viral channel-forming proteins comprise a class of viral proteins which, similar to their host companions, are made to alter electrochemical or substrate gradients across lipid membranes. These proteins are active during all stages of the cellular life cycle of viruses. An increasing number of proteins are identified as channel proteins, but the precise role in the viral life cycle is yet unknown for the majority of them. This review presents an overview about these proteins with an emphasis on those with available structural information.A concept is introduced which aligns the transmembrane domains of viral channel proteins with those of host channels and toxins to give insights into the mechanism of function of the viral proteins from potential sequence identities. A summary of to date investigations on drugs targeting these proteins is given and discussed in respect of their mode of action in vivo.

原文English
主出版物標題International Review of Cell and Molecular Biology
發行者Elsevier Inc.
頁面259-321
頁數63
DOIs
出版狀態Published - 2012

出版系列

名字International Review of Cell and Molecular Biology
294
ISSN(列印)1937-6448

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