TY - JOUR
T1 - Mapping billions of short reads to a reference genome
AU - Hung, Jui-Hung
AU - Weng, Zhiping
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Rapid development and commercialization of instruments that can accurately, rapidly, and cheaply sequence billions of DNA bases is revolutionizing molecular biology and medicine. Because a reference genome is usually available, the first bioinformatics challenge presented by the new generation of highthroughput sequencers is the genome mapping problem, where each read is mapped to a reference genome to reveal its location(s). An introduction to mapping algorithms, as well as factors that influence their results, is provided here.
AB - Rapid development and commercialization of instruments that can accurately, rapidly, and cheaply sequence billions of DNA bases is revolutionizing molecular biology and medicine. Because a reference genome is usually available, the first bioinformatics challenge presented by the new generation of highthroughput sequencers is the genome mapping problem, where each read is mapped to a reference genome to reveal its location(s). An introduction to mapping algorithms, as well as factors that influence their results, is provided here.
UR - http://www.scopus.com/inward/record.url?scp=85008500377&partnerID=8YFLogxK
U2 - 10.1101/pdb.top093153
DO - 10.1101/pdb.top093153
M3 - Article
C2 - 27574203
AN - SCOPUS:85008500377
SN - 1940-3402
VL - 2017
SP - 14
EP - 17
JO - Cold Spring Harbor Protocols
JF - Cold Spring Harbor Protocols
IS - 1
ER -