TY - JOUR
T1 - Magnetically Guided Theranostics
T2 - Optimizing Magnetic Resonance Imaging with Sandwich-Like Kaolinite-Based Iron/Platinum Nanoparticles for Magnetic Fluid Hyperthermia and Chemotherapy
AU - Chan, Ming Hsien
AU - Hsieh, Ming Ren
AU - Liu, Ru Shi
AU - Wei, Da Hua
AU - Hsiao, Michael
N1 - Publisher Copyright:
Copyright © 2019 American Chemical Society.
PY - 2020/1/28
Y1 - 2020/1/28
N2 - Hepatocellular carcinoma (HCC) is a common type of liver cancer that can be diagnosed by magnetic resonance imaging (MRI). If diagnosing HCC by basic MRI is difficult, then doctors use T1-weighted or T2-weighted imaging with a contrast agent that has long-term retention in the liver, such as Fe3O4 or FePt, to aid in MRI diagnosis. One challenging goal of cancer prevention is developing a method that can further treat or inhibit HCC cells at the time of diagnosis. Functionalized porous kaolinite can serve not only as a drug delivery system for treating cancer cells but also as a scaffold to carry FePt nanoparticles (FePt NPs) and drugs such as doxorubicin (Dox). FePt NPs combined with kaolinite modified with cetyltrimethylammonium bromide (CTAB) can form FePt@Kao nanocomposites. Multifunctional FePt@Kao can serve as a magnetic fluid hyperthermia (MFH) agent that can also be used to simultaneously visualize and treat HCC cancer cells. After being loaded with the chemotherapeutic drug Dox, FePt@Kao-Dox can provide both MFH treatment and chemotherapy. From the systematic analysis results, we demonstrated that this functionalized FePt@Kao-Dox nanocomposite can be successfully used as a platform to integrate MRI, magnetically guided targeting, and therapeutic treatment into a multifunctional drug delivery system.
AB - Hepatocellular carcinoma (HCC) is a common type of liver cancer that can be diagnosed by magnetic resonance imaging (MRI). If diagnosing HCC by basic MRI is difficult, then doctors use T1-weighted or T2-weighted imaging with a contrast agent that has long-term retention in the liver, such as Fe3O4 or FePt, to aid in MRI diagnosis. One challenging goal of cancer prevention is developing a method that can further treat or inhibit HCC cells at the time of diagnosis. Functionalized porous kaolinite can serve not only as a drug delivery system for treating cancer cells but also as a scaffold to carry FePt nanoparticles (FePt NPs) and drugs such as doxorubicin (Dox). FePt NPs combined with kaolinite modified with cetyltrimethylammonium bromide (CTAB) can form FePt@Kao nanocomposites. Multifunctional FePt@Kao can serve as a magnetic fluid hyperthermia (MFH) agent that can also be used to simultaneously visualize and treat HCC cancer cells. After being loaded with the chemotherapeutic drug Dox, FePt@Kao-Dox can provide both MFH treatment and chemotherapy. From the systematic analysis results, we demonstrated that this functionalized FePt@Kao-Dox nanocomposite can be successfully used as a platform to integrate MRI, magnetically guided targeting, and therapeutic treatment into a multifunctional drug delivery system.
UR - http://www.scopus.com/inward/record.url?scp=85078672700&partnerID=8YFLogxK
U2 - 10.1021/acs.chemmater.9b03552
DO - 10.1021/acs.chemmater.9b03552
M3 - Article
AN - SCOPUS:85078672700
SN - 0897-4756
VL - 32
SP - 697
EP - 708
JO - Chemistry of Materials
JF - Chemistry of Materials
IS - 2
ER -