Magnetic resonance imaging signal characteristics associated with prognosis of skull base chordoma after gamma knife radiosurgery

Yong Sin Hu, Cheng Chia Lee, Chia An Wu, Chung Jung Lin, Huai Che Yang, Wan Yuo Guo, Kang Du Liu, Wen Yuh Chung, Cheng Ying Shiau, Hsiu Mei Wu*

*此作品的通信作者

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

Objective: To investigate the association between the magnetic resonance imaging (MRI) signal characteristics of skull base chordoma and radiosurgical outcomes. Methods: Twenty-four patients with skull base chordomas treated with Gamma Knife radiosurgery (GKRS) after previous surgical resection were retrospectively (2001–2021) examined. Pre-GKRS MRIs were analyzed for RT2 (tumor-to-brainstem signal intensity ratio on T2-weighted imaging), RCE (tumor-to-brainstem signal intensity ratio on contrast-enhanced T1-weighted imaging), and mean apparent diffusion coefficient (ADC). Correlations of the parameters with patient survival and local tumor progression were made by using Cox regression and Kaplan–Meier analyses. Results: During a median follow-up of 46 months after GKRS, 9 patients died with significantly more local tumor progression events (median number: 2 vs 0, P =.012) than did 15 alive patients. On multivariable analysis, higher mean ADC was associated with longer patient survival (P =.016) after GKRS. The actuarial 5-year overall survival rates were 88.9% versus 54.7% for chordomas with an ADC of ≥ 1270 × 10–6 mm2/s versus < 1270 × 10–6 mm2/s. RT2 < 1.5 (P =.038) and RCE > 1.57 (P =.022) were associated with a lower probability of local tumor control. Conclusion: Lower mean ADC values are associated with shorter patient survival in skull base chordomas after GKRS. Diffusion-weighted imaging may help in GKRS planning and outcome prediction for these patients.

原文English
期刊Journal of Neuro-Oncology
DOIs
出版狀態Accepted/In press - 2022

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